<main>
    <div class="red"></div>
    <div class="orange"></div>
    <div class="blue"></div>
    <div class="lime"></div>
  </main>

  <main2>
    <div class="orange2"></div>
    <div class="blue2"> </div>
    <div class="red2"></div>
    <div class="lime2"></div>
  </main2>

  <main3>
    <div class="red"></div>
    <div class="orange"></div>
    <div class="blue"></div>
    <div class="lime"></div>
  </main3>

  <div></div>

index.html

body {
    margin: 0;
  }
  main {
    display: flex;
    flex-direction: row;
    flex-wrap: wrap;
   }

  main2 {
    display: flex;
    flex-direction: row;
    flex-wrap: wrap;
    align-content: center;
  }

  main3 {
    display: flex;
    flex-direction: column;
    flex-wrap: wrap-reverse;
    justify-content: flex-end;
    align-items: stretch;
  }

  .red {
    background-color: red;
    width: 400px;
    height: 200px;
  }
  .red2 {
    background-color: red;
    width: 600px;
    height: 200px;
  }

  .orange {
    background-color: #f47b00;
    width: 400px;
    height: 200px;
  }

  .orange2 {
    background-color: #f47b00;
    width: 300px;
    height: 600px;
  }

  .blue {
    background-color: blue;
    width: 400px;
    height: 800px;
  }

  .blue2 {
    background-color: blue;
    width: 4000px;
    height: 400px;
  }

  .lime {
    background-color: lime;
    width: 100%;
    height: 450px;
  }
  .lime2 {
    background-color: lime;
    width: 4000px;
    height: 200px;
  }

  div {
  background-color: red;
    width: 300px;
    height: 100px;
    border: none;
  }

index.css